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III A Continuation of Facts and Observations Relative to the Various Vaccines, or Cow–Pox. 1800
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 III
A Continuation of Facts and Observations Relative to the Various Vaccines1, or Cow–Pox. 1800
 
Since my former publications on the vaccine2 inoculation3 I have had the satisfaction of seeing it extend very widely. Not only in this country is the subject pursued with ardour, but from my correspondence with many respectable medical gentlemen on the Continent (among whom are Dr. De Carro, of Vienna, and Dr. Ballhorn, of Hanover) I find it is as warmly adopted abroad, where it has afforded the greatest satisfaction. I have the pleasure, too, of seeing that the feeble efforts of a few individuals to depreciate4 the new practice are sinking fast into contempt beneath the immense mass of evidence which has arisen up in support of it.
 
Upwards5 of six thousand persons have now been inoculated7 with the virus of cow-pox, and the far greater part of them have since been inoculated with that of smallpox8, and exposed to its infection in every rational way that could be devised, without effect.
 
It was very improbable that the investigation9 of a disease so analogous10 to the smallpox should go forward without engaging the attention of the physician of the Smallpox Hospital in London.
 
Accordingly, Dr. Woodville, who fills that department with so much respectability, took an early opportunity of instituting an inquiry11 into the nature of the cow-pox. This inquiry was begun in the early part of the present year, and in May, Dr. Woodville published the result, which differs essentially12 from mine in a point of much importance. It appears that three-fifths of the patients inoculated were affected13 with eruptions15, for the most part so perfectly16 resembling the smallpox as not to be distinguished17 from them. On this subject it is necessary that I should make some comments.
 
When I consider that out of the great number of cases of casual inoculation immediately from cows which from time to time presented themselves to my observation, and the many similar instances which have been communicated to me by medical gentlemen in this neighbourhood; when I consider, too, that the matter with which my inoculations were conducted in the years 1797, ‘98, and ‘99, was taken from some different cows, and that in no instance any thing like a variolous pustule appeared, I cannot feel disposed to imagine that eruptions, similar to those described by Dr. Woodville, have ever been produced by the pure uncontaminated cow-pock virus; on the contrary, I do suppose that those which the doctor speaks of originated in the action of variolous matter which crept into the constitution with the vaccine. And this I presume happened from the inoculation of a great number of the patients with variolous matter (some on the third, others on the fifth, day) after the vaccine had been applied18; and it should be observed that the matter thus propagated became the source of future inoculations in the hands of many medical gentlemen who appeared to have been previously19 unacquainted with the nature of the cow-pox.
 
Another circumstance strongly, in my opinion, supporting this supposition is the following: The cow-pox has been known among our dairies time immemorial. If pustules, then, like the variolous, were to follow the communication of it from the cow to the milker, would not such a fact have been known and recorded at our farms? Yet neither our farmers nor the medical people of the neighbourhood have noticed such an occurrence.
 
A few scattered21 pimples22 I have sometimes, though very rarely, seen, the greater part of which have generally disappeared quickly, but some have remained long enough to suppurate at their apex23. That local cuticular24 inflammation, whether springing up spontaneously or arising from the application of acrid25 substances, such for instance, as cantharides, pix Burgundica, antimonium tartarizatum, etc., will often produce cutaneous affections, not only near the seat of the inflammation, but on some parts of the skin far beyond its boundary, is a well-known fact. It is, doubtless, on this principle that the inoculated cow-pock pustule and its concomitant efflorescence may, in very irritable26 constitutions, produce this affection. The eruption14 I allude27 to has commonly appeared some time in the third week after inoculation. But this appearance is too trivial to excite the least regard.
 
The change which took place in the general appearance during the progress of the vaccine inoculation at the Smallpox Hospital should likewise be considered.
 
Although at first it took on so much of the variolous character as to produce pustules in three cases out of five, yet in Dr. Woodville’s last report, published in June, he says: “Since the publication of my reports of inoculations for the cow-pox, upwards of three hundred cases have been under my care; and out of this number only thirty-nine had pustules that suppurated; viz., out of the first hundred, nineteen had pustules; out of the second, thirteen; and out of the last hundred and ten, only seven had pustules. Thus it appears that the disease has become considerably28 milder; which I am inclined to attribute to a greater caution used in the choice of the matter, with which the infection was communicated; for, lately, that which has been employed for this purpose has been taken only from those patients in whom the cow-pox proved very mild and well characterized.” 31
 
The inference I am induced to draw from these premises29 is very different. The decline, and, finally, the total extinction30 nearly, of these pustules, in my opinion, are more fairly attributable to the cow-pox virus, assimilating the variolous,32 the former probably being the original, the latter the same disease under a peculiar31, and at present an inexplicable32, modification33.
 
One experiment tending to elucidate34 the point under discussion I had myself an opportunity of instituting. On the supposition of its being possible that the cow which ranges over the fertile meadows in the vale of Gloucester might generate a virus differing in some respects in its qualities from that produced by the animal artificially pampered35 for the production of milk for the metropolis36, I procured38, during my residence there in the spring, some cow pock virus from a cow at one of the London milk-farms. 33 It was immediately conveyed into Gloucestershire to Dr. Marshall, who was then extensively engaged in the inoculation of the cow-pox, the general result of which, and of the inoculation in particular with this matter, I shall lay before my reader in the following communication from the doctor:
 
“Dear Sir:
 
“My neighbour, Mr. Hicks, having mentioned your wish to be informed of the progress of the inoculation here for the cow-pox, and he also having taken the trouble to transmit to you my minutes of the cases which have fallen under my care, I hope you will pardon the further trouble I now give you in stating the observations I have made upon the subject. When first informed of it, having two children who had not had the smallpox, I determined39 to inoculate6 them for the cow-pox whenever I should be so fortunate as to procure37 matter proper for the purpose. I was, therefore, particularly happy when I was informed that I could procure matter from some of those whom you had inoculated. In the first instance I had no intention of extending the disease further than my own family, but the very extensive influence which the conviction of its efficacy in resisting the smallpox has had upon the minds of the people in general has rendered that intention nugatory40, as you will perceive, by the continuation of my cases enclosed in this letter,34 by which it will appear that since the 22d of March I have inoculated an hundred and seven persons; which, considering the retired41 situation I resided in, is a very great number. There are also other considerations which, besides that of its influence in resisting the smallpox, appear to have had their weight; the peculiar mildness of the disease, the known safety of it, and its not having in any instance prevented the patient from following his ordinary business. In all the cases under my care there have only occurred two or three which required any application, owing to erysipelatous inflammation on the arm, and they immediately yielded to it. In the remainder the constitutional illness has been slight but sufficiently42 marked, and considerably less than I ever observed in the same number inoculated with the smallpox. In only one or two of the cases have any other eruptions appeared than those around the spot where the matter was inserted, and those near the infected part. Neither does there appear in the cow-pox to be the least exciting cause to any other disease, which in the smallpox has been frequently observed, the constitution remaining in as full health and vigour43 after the termination of the disease as before the infection. Another important consideration appears to be the impossibility of the disease being communicated except by the actual contact of the matter of the pustule, and consequently the perfect safety of the remaining part of the family, supposing only one or two should wish to be inoculated at the same time.
 
“Upon the whole, it appears evident to me that the cow-pox is a pleasanter, shorter, and infinitely44 more safe disease than the inoculated smallpox when conducted in the most careful and approved manner; neither is the local affection of the inoculated part, or the constitutional illness, near so violent. I speak with confidence on the subject, having had an opportunity of observing its effects upon a variety of constitutions, from three months old to sixty years; and to which I have paid particular attention. In the cases alluded45 to here you will observe that the removal from the original source of the matter had made no alteration46 or change in the nature or appearance of the disease, and that it may be continued, ad infinitum (I imagine), from one person to another (if care be observed in taking the matter at a proper period) without any necessity of recurring47 to the original matter of the cow.
 
“I should be happy if any endeavours of mine could tend further to elucidate the subject, and shall be much gratified is sending you any further observations I may be enabled to make.
 
“I have the pleasure to subscribe48 myself,
“Dear sir, etc.,
“Joseph H. Marshall
 
“Eastington, Gloucestershire, April 26, 1799.”
 
The gentleman who favoured me with the above account has continued to prosecute49 his inquiries50 with unremitting industry, and has communicated the result in another letter, which at his request I lay before the public without abbreviation.
 
Dr. Marshall’s second letter:
 
“Dear Sir:
 
“Since the date of my former letter I have continued to inoculate with the cow-pox virus. Including the cases before enumerated51, the number now amounts to four hundred and twenty-three. It would be tedious and useless to detail the progress of the disease in each individual — it is sufficient to observe that I noticed no deviation52 in any respect from the cases I formerly53 adduced. The general appearances of the arm exactly corresponded with the account given in your first publication. When they were disposed to become troublesome by erysipelatous inflammation, an application of equal parts of vinegar and water always answered the desired intention. I must not omit to inform you that when the disease had duly acted upon the constitution I have frequently used the vitriolic54 acid. A portion of a drop applied with the head of a probe or any convenient utensil55 upon the pustule, suffered to remain about forty seconds, and afterwards washed off with sponge and water, never failed to stop its progress and expedite the formation of a scab.
 
“I have already subjected two hundred and eleven of my patients to the action of variolous matter, but every one resisted it.
 
“The result of my experiments (which were made with every requisite56 caution) has fully57 convinced me that the true cow-pox is a safe and infallible preventive from the smallpox; that in no case which has fallen under my observation has it been in any considerable degree troublesome, much less have I seen any thing like danger; for in no instance were the patients prevented from following their ordinary employments.
 
“In Dr. Woodville’s publication on the cow-pox I notice an extraordinary fact. He says that the generality of his patients had pustules. It certainly appears extremely extraordinary that in all my cases there never was but one pustule, which appeared on a patient’s elbow on the inoculated arm, and maturated. It appeared exactly like that on the incised part.
 
“The whole of my observations, founded as it appears on an extensive experience, leads me to these obvious conclusions; that those cases which have been or may be adduced against the preventive powers of the cow-pox could not have been those of the true kind, since it must appear to be absolutely impossible that I should have succeeded in such a number of cases without a single exception if such a preventive power did not exist. I cannot entertain a doubt that the inoculated cow-pox must quickly supersede58 that of the smallpox. If the many important advantages which must result from the new practice are duly considered, we may reasonably infer that public benefit, the sure test of the real merit of discoveries, will render it generally extensive.
 
“To you, Sir, as the discoverer of this highly beneficial practice, mankind are under the highest obligations. As a private individual I participate in the general feeling; more particularly as you have afforded me an opportunity of noticing the effects of a singular disease, and of viewing the progress of the most curious experiment that ever was recorded in the history of physiology59.
 
“I remain, dear sir, etc.,
“Joseph H. Marshall.”
 
“P.S. I should have observed that, of the patients I inoculated and enumerated in my letter, one hundred and twenty-seven were infected with the matter you sent me from the London cow. I discovered no dissimilarity of symptoms in these cases from those which I inoculated from matter procured in this country. No pustules have occurred, except in one or two cases, where a single one appeared on the inoculated arm. No difference was apparent in the local inflammation. There was no suspension of ordinary employment among the labouring people, nor was any medicine required.
 
“I have frequently inoculated one or two in a family, and the remaining part of it some weeks afterwards. The uninfected have slept with the infected during the whole course of the disease without being affected; so that I am fully convinced that the disease cannot be taken but by actual contact with the matter.
 
“A curious fact has lately fallen under my observation, on which I leave you to comment.
 
“I visited a patient with the confluent smallpox and charged a lancet with some of the matter. Two days afterwards I was desired to inoculate a woman and four children with the cow-pox, and I inadvertently took the vaccine matter on the same lancet which was before charged with that of smallpox. In three days I discovered the mistake, and fully expected that my five patients would be infected with smallpox; but I was agreeably surprised to find the disease to be genuine cow-pox, which proceeded without deviating60 in any particular from my former cases. I afterwards inoculated these patients with variolous matter, but all of them resisted its action.
 
“I omitted mentioning another great advantage that now occurs to me in the inoculated cow-pox; I mean, the safety with which pregnant women may have the disease communicated to them. I have inoculated a great number of females in that situation, and never observed their cases to differ in any respect from those of my other patients. Indeed, the disease is so mild that it seems as if it might at all times be communicated with the most perfect safety.”
 
I shall here take the opportunity of thanking Dr. Marshall and those other gentlemen who have obligingly presented me with the result of their inoculations; but, as they all agree in the same point as that given in the above communication, namely, the security of the patient from the effects of the smallpox after the cow-pox, their perusal61, I presume, would afford us no satisfaction that has not been amply given already. Particular occurrences I shall, of course, detail. Some of my correspondents have mentioned the appearance of smallpox-like eruptions at the commencement of their inoculations; but in these cases the matter was derived62 from the original stock at the Smallpox Hospital.
 
I have myself inoculated a very considerable number from the matter produced by Dr. Marshall’s patients, originating in the London cow, without observing pustules of any kind, and have dispersed63 it among others who have used it with a similar effect. From this source Mr. H. Jenner informs me he has inoculated above an hundred patients without observing eruptions. Whether the nature of the virus will undergo any change from being farther removed from its original source in passing successively from one person to another time alone can determine. That which I am now employing has been in use near eight months, and not the least change is perceptible in its mode of action either locally or constitutionally. There is, therefore, every reason to expect that its effects will remain unaltered and that we shall not be under the necessity of seeking fresh supplies from the cow.
 
The following observations were obligingly sent me by Mr. Tierny, Assistant Surgeon to the South Gloucester Regiment64 of Militia65, to whom I am indebted for a former report on this subject:
 
“I inoculated with the cow-pox matter from the eleventh to the latter part of April, twenty-five persons, including women and children. Some on the eleventh were inoculated with the matter Mr. Shrapnell (surgeon to the regiment) had from you, the others with matter taken from these. The progress of the puncture66 was accurately67 observed, and its appearance seemed to differ from the smallpox in having less inflammation around its basis on the first days — that is, from the third to the seventh; but after this the inflammation increased, extending on the tenth or eleventh day to a circle of an inch and a half from its centre, and threatening very sore arms; but this I am happy to say was not the case; for, by applying mercurial68 ointment69 to the inflamed70 part, which was repeated daily until the inflammation went off, the arm got well without any further application or trouble. The constitutional symptoms which appeared on the eighth or ninth day after inoculation scarcely deserved the name of disease, as they were so slight as to be scarcely perceptible, except that I could connect a slight headache and languor71, with a stiffness and rather painful sensation in the axilla. This latter symptom was the most striking — it remained from twelve to forty-eight hours. In no case did I observe the smallest pustule, or even discolouration of the skin, like an incipient72 pustule, except about the part where the virus has been applied.
 
“After all these symptoms had subsided73 and the arms were well, I inoculated four of this number with variolous matter, taken from a patient in another regiment. In each of these it was inserted several times under the cuticle74, producing slight inflammation on the second or third day, and always disappearing before the fifth or sixth, except in one who had the cow-pox in Gloucestershire before he joined us, and who also received it at this time by inoculation. In this man the puncture inflamed and his arm was much sorer than from the insertion of the cow-pox virus; but there was no pain in the axilla, nor could any constitutional affection be observed.
 
“I have only to add that I am now fully satisfied of the efficacy of the cow-pox in preventing the appearance of the smallpox, and that it is a most happy and salutary substitute for it. I remain, etc.,
 
“M. J. Tierny.”
 
Although the susceptibility of the virus of the cow-pox is, for the most part, lost in those who have had the smallpox, yet in some constitutions it is only partially75 destroyed, and in others it does not appear to be in the least diminished.
 
By far the greater number on whom trials were made resisted it entirely76; yet I found some on whose arm the pustule from inoculation was formed completely, but without producing the common efflorescent blush around it, or any constitutional illness, while others have had the disease in the most perfect manner. A case of the latter kind having been presented to me by Mr. Fewster, Surgeon, of Thornbury, I shall insert it:
 
“Three children were inoculated with the vaccine matter you obligingly sent me. On calling to look at their arms three days after I was told that John Hodges, one of the three, had been inoculated with the smallpox when a year old, and that he had a full burthen, of which his face produced plentiful77 marks, a circumstance I was not before made acquainted with. On the sixth day the arm of the boy appeared as if inoculated with variolous matter, but the pustule was rather more elevated. On the ninth day he complained of violent pain in his head and back, accompanied with vomiting78 and much fever. The next day he was very well and went to work as usual. The punctured79 part began to spread, and there was the areola around the inoculated part to a considerable extent.
 
“As this is contrary to an assertion made in the Medical and Physical Journal, No. 8, I thought it right to give you this information, and remain,
 
“Dear sir, etc.,
“J. Fewster.”
 
It appears, then, that the animal economy with regard to the action of this virus is under the same laws as it is with respect to the variolous virus, after previously feeling its influence, as far as comparisons can be made between the two diseases.
 
Some striking instances of the power of the cow-pox in suspending the progress of the smallpox after the patients had been several days casually80 exposed to the infection have been laid before me by Mr. Lyford, Surgeon, of Winchester, and my nephew, the Rev20. G. C Jenner. Mr. Lyford, after giving an account of his extensive and successful practice in the vaccine inoculation in Hampshire, writes as follows:
 
“The following case occurred to me a short time since, and may probably be worth your notice. I was sent for to a patient with the smallpox, and on inquiry found that five days previous to my seeing him the eruption began to appear. During the whole of this time two children who had not had the smallpox, were constantly in the room with their father, and frequently on the bed with him. The mother consulted me on the propriety81 of inoculating82 them, but objected to my taking the matter from their father, as he was subject to erysipelas. I advised her by all means to have them inoculated at that time, as I could not procure any variolous matter elsewhere. However, they were inoculated with vaccine matter, but I cannot say I flattered myself with its proving successful, as they had previously been so long and still continued to be exposed to the variolous infection. Notwithstanding this I was agreeably surprised to find the vaccine disease advance and go through its regular course; and, if I may be allowed the expression, to the total extinction of the smallpox.”
 
Mr. Jenner’s cases were not less satisfactory. He writes as follows:
 
“A son of Thomas Stinchcomb, of Woodford, near Berkeley, was infected with the natural smallpox at Bristol, and came home to his father’s cottage. Four days after the eruptions had appeared upon the boy, the family (none of which had ever had the smallpox), consisting of the father, mother, and five children, was inoculated with vaccine virus. On the arm of the mother it failed to produce the least effect, and she, of course, had the smallpox, 35 but the rest of the family had the cow-pox in the usual way, and were not affected with the smallpox, although they were in the same room, and the children slept in the same bed with their brother who was confined to it with the natural smallpox; and subsequently with their mother.
 
“I attended this family with my brother, Mr. H. Jenner.”
 
The following cases are of too singular a nature to remain unnoticed.
 
Miss R — a young lady about five years old, was seized on the evening of the eighth day after inoculation with vaccine virus, with such symptoms as commonly denote the accession of violent fever. Her throat was also a little sore, and there were some uneasy sensations about the muscles of the neck. The day following a rash was perceptible on her face and neck, so much resembling the efflorescence of the scarlatina anginosa that I was induced to ask whether Miss R— had been exposed to the contagion83 of that disease. An answer in the affirmative, and the rapid spreading of the redness over the skin, at once relieved me from much anxiety respecting the nature of the malady84, which went through its course in the ordinary way, but not without symptoms which were alarming both to myself and Mr. Lyford, who attended with me. There was no apparent deviation in the ordinary progress of the pustule to a state of maturity85 from what we see in general; yet there was a total suspension of the areola or florid discolouration around it, until the scarlatina had retired from the constitution. As soon as the patient was freed from this disease this appearance advanced in the usual way.36
 
The case of Miss H— R— is not less interesting than that of her sister, above related. She was exposed to the contagion of the scarlatina at the same time, and sickened almost at the same hour. The symptoms continued severe about twelve hours, when the scarlatina-rash shewed itself faintly upon her face, and partly upon her neck. After remaining two or three hours it suddenly disappeared, and she became perfectly free from every complaint. My surprise at this sudden transition from extreme sickness to health in great measure ceased when I observed that the inoculated pustule had occasioned, in this case, the common efflorescent appearance around it, and that as it approached the centre it was nearly in an erysipelatous state. But the most remarkable86 part of this history is that, on the fourth day afterwards, so soon as the efflorescence began to die away upon the arm and the pustule to dry up, the scarlatina again appeared, her throat became sore, the rash spread all over her. She went fairly through the disease with its common symptoms.
 
That these were actually cases of scarlatina was rendered certain by two servants in the family falling ill at the same time with the distemper, who had been exposed to the infection with the young ladies.
 
Some there are who suppose the security from the smallpox obtained through the cow-pox will be of a temporary nature only. This supposition is refuted not only by analogy with respect to the habits of diseases of a similar nature, but by incontrovertible facts, which appear in great numbers against it. To those already adduced in the former part of my first treatise37 many more might be adduced were it deemed necessary; but among the cases I refer to, one will be found of a person who had the cow-pox fifty-three years before the effect of the smallpox was tried upon him. As he completely resisted it, the intervening period I conceive must necessarily satisfy any reasonable mind. Should further evidence be thought necessary, I shall observe that, among the cases presented to me by Mr. Fry, Mr. Darke, Mr. Tierny, Mr. H. Jenner, and others, there were many whom they inoculated ineffectually with variolous matter, who had gone through the cow-pox many years before this trial was made.
 
It has been imagined that the cow-pox is capable of being communicated from one person to another by effluvia without the intervention87 of inoculation. My experiments, made with the design of ascertaining88 this important point, all tend to establish my original position, that it is not infectious except by contact, I have never hesitated to suffer those on whose arms there were pustules exhaling89 the effluvia from associating or even sleeping with others who never had experienced either the cow-pox or the smallpox. And, further, I have repeatedly, among children, caused the uninfected to breathe over the inoculated vaccine ‘pustules during their whole progress, yet these experiments were tried without the least effect. However, to submit a matter so important to a still further scrutiny90, I desired Mr. H. Jenner to make any further experiments which might strike him as most likely to establish or refute what had been advanced on this subject. He has since informed me “that he inoculated children at the breast, whose mothers had not gone through either the smallpox or the cow-pox; that he had inoculated mothers whose sucking infants had never undergone either of these diseases; that the effluvia from the inoculated pustules, in either case, had been inhaled91 from day to day during the whole progress of their maturation, and that there was not the least perceptible effect from these exposures.” One woman he inoculated about a week previous to her accouchement, that her infant might be the more fully and conveniently exposed to the pustule; but, as in the former instances, no infection was given, although the child frequently slept on the arm of its mother with its nostrils92 and mouth exposed to the pustule in the fullest state of maturity. In a word, is it not impossible for the cow-pox, whose only manifestation93 appears to consist in the pustules created by contact, to produce itself by effluvia?
 
In the course of a late inoculation I observed an appearance which it may be proper here to relate. The punctured part on a boy’s arm (who was inoculated with fresh limpid94 virus) on the sixth day, instead of shewing a beginning vesicle, which is usual in the cow-pox at that period, was encrusted over with a rugged95, amber-coloured scab. The scab continued to spread and increase in thickness for some days, when, at its edges, a vesicated ring appeared, and the disease went through its ordinary course, the boy having had soreness in the axilla and some slight indisposition. With the fluid matter taken from his arm five persons were inoculated. In one it took no effect. In another it produced a perfect pustule without any deviation from the common appearance; but in the other three the progress of the inflammation was exactly similar to the instance which afforded the virus for their inoculation; there was a creeping scab of a loose texture96, and subsequently the formation of limpid fluid at its edges. As these people were all employed in laborious97 exercises, it is possible that these anomalous98 appearances might owe their origin to the friction99 of the clothes on the newly inflamed part of the arm. I have not yet had an opportunity of exposing them to the smallpox.
 
In the early part of this inquiry I felt far more anxious respecting the inflammation of the inoculated arm than at present; yet that this affection will go on to a greater extent than could be wished is a circumstance sometimes to be expected. As this can be checked, or even entirely subdued100, by very simple means, I see no reason why the patient should feel an uneasy hour because an application may not be absolutely necessary. About the tenth or eleventh day, if the pustule has proceeded regularly, the appearance of the arm will almost to a certainty indicate whether this is to be expected or not. Should it happen, nothing more need be done than to apply a single drop of the aqua lythargyri acetati 38 upon the pustule, and, having suffered it to remain two or three minutes, to cover the efflorescence surrounding the pustule with a piece of linen101 dipped in the aqua lythargyri compos.39 The former may be repeated twice or thrice during the day, the latter as often as it may feel agreeable to the patient.
 
When the scab is prematurely102 rubbed off (a circumstance not unfrequent among children and working people), the application of a little aqua lythargyri acet. to the part immediately coagulates the surface, which supplies its place, and prevents a sore.
 
In my former treatises103 on this subject I have remarked that the human constitution frequently retains its susceptibility to the smallpox contagion (both from effluvia and contact) after previously feeling its influence. In further corroboration104 of this declaration many facts have been communicated to me by various correspondents. I shall select one of them.
 
“Dear Sir:
 
“Society at large must, I think, feel much indebted to you for your Inquiries and Observations on the Nature and Effects of the Variolae Vaccinae, etc., etc. As I conceive what I am now about to communicate to be of some importance, I imagine it cannot be uninteresting to you, especially as it will serve to corroborate105 your assertion of the susceptibility of the human system of the variolous contagion, although it has previously been made sensible of its action. In November, 1793, I was desired to inoculate a person with the smallpox. I took the variolous matter from a child under the disease in the natural way, who had a large burthen of distinct pustules. The mother of the child being desirous of seeing my method of communicating the disease by inoculation, after having opened a pustule, I introduced the point of my lancet in the usual way on the back part of my own hand, and thought no more of it until I felt a sensation in the part which reminded me of the transaction. This happened upon the third day; on the fourth there were all the appearances common to inoculation, at which I was not at all surprised, nor did I feel myself uneasy upon perceiving the inflammation continue to increase to the sixth and seventh day, accompanied with a very small quantity of fluid, repeated experiments having taught me it might happen so with persons who had undergone the disease, and yet would escape any constitutional affection; but I was not so fortunate; for on the eighth day I was seized with all the symptoms of the eruptive fever, but in a much more violent degree than when I was before inoculated, which was about eighteen years previous to this, when I had a considerable number of pustules. I must confess I was now greatly alarmed, although I had been much engaged in the smallpox, having at different times inoculated not less than two thousand persons. I was convinced my present indisposition proceeded from the insertion of the variolous matter, and, therefore, anxiously looked for an eruption. On the tenth day I felt a very unpleasant sensation of stillness and heat on each side of my face near my ear, and the fever began to decline. The affection in my face soon terminated in three or four pustules attended with inflammation, but which did not maturate, and I was presently well.
 
“I remain, dear sir, etc.,
“Thomas Miles.”
 
This inquiry is not now so much in its infancy106 as to restrain me from speaking more positively107 than formerly on the important point of scrophula as connected with the smallpox.
 
Every practitioner108 in medicine who has extensively inoculated with the smallpox, or has attended many of those who have had the distemper in the natural way, must acknowledge that he has frequently seen scrophulous affections, in some form or another, sometimes rather quickly shewing themselves after the recovery of the patients. Conceiving this fact to be admitted, as I presume it must be by all who have carefully attended to the subject, may I not ask whether it does not appear probable that the general introduction of the smallpox into Europe has not been among the most conductive means in exciting that formidable foe109 to health? Having attentively110 watched the effects of the cow-pox in this respect, I am happy in being able to declare that the disease does not appear to have the least tendency to produce this destructive malady.
 
The scepticism that appeared, even among the most enlightened of medical men when my sentiments on the important subject of the cow-pox were first promulgated111, was highly laudable. To have admitted the truth of a doctrine112, at once so novel and so unlike any thing that ever had appeared in the annals of medicine, without the test of the most rigid113 scrutiny, would have bordered upon temerity114; but now, when that scrutiny has taken place, not only among ourselves, but in the first professional circles in Europe, and when it has been uniformly found in such abundant instances that the human frame, when once it has felt the influence of the genuine cow-pox in the way that has been described, is never afterwards at any period of its existence assailable115 by the smallpox, may I not with perfect confidence congratulate my country and society at large on their beholding116, in the mild form of the cow-pox, an antidote117 that is capable of extirpating118 from the earth a disease which is every hour devouring119 its victims; a disease that has ever been considered as the severest scourge120 of the human race!

点击收听单词发音收听单词发音  

1 vaccines c9bb57973a82c1e95c7cd0f4988a1ded     
疫苗,痘苗( vaccine的名词复数 )
参考例句:
  • His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
  • The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。
2 vaccine Ki1wv     
n.牛痘苗,疫苗;adj.牛痘的,疫苗的
参考例句:
  • The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
3 inoculation vxvyj     
n.接芽;预防接种
参考例句:
  • Travellers are reminded that inoculation against yellow fever is advisable. 提醒旅游者接种预防黄热病的疫苗是明智的。 来自《简明英汉词典》
  • Travelers are reminded that inoculation against yellow fever is advisable. 旅客们被提醒,注射黄热病预防针是明智的。 来自辞典例句
4 depreciate Pmpz0     
v.降价,贬值,折旧
参考例句:
  • The computer value will depreciate by $ 500 in the first year.在头一年里这台电脑会贬值500美元。
  • If you neglect this property,it will depreciate.如果你忽视这份资产,它无形中就贬值了。
5 upwards lj5wR     
adv.向上,在更高处...以上
参考例句:
  • The trend of prices is still upwards.物价的趋向是仍在上涨。
  • The smoke rose straight upwards.烟一直向上升。
6 inoculate 5x1yk     
v.给...接种,给...注射疫苗
参考例句:
  • A corps of doctors arrived to inoculate the recruits.一队医生来给新兵打防疫针。
  • I was just meant to come out here and inoculate some wee babies.我是过来这边给小孩子们接种疫苗的。
7 inoculated 6f20d8c4f94d9061a1b3ff05ba9dcd4a     
v.给…做预防注射( inoculate的过去式和过去分词 )
参考例句:
  • A pedigree pup should have been inoculated against serious diseases before it's sold. 纯种狗应该在出售前注射预防严重疾病的针。 来自《简明英汉词典》
  • Disease can be spread by dirty tools, insects, inoculated soil. 疾病也能由不干净的工具,昆虫,接种的土壤传播。 来自辞典例句
8 smallpox 9iNzJw     
n.天花
参考例句:
  • In 1742 he suffered a fatal attack of smallpox.1742年,他染上了致命的天花。
  • Were you vaccinated against smallpox as a child?你小时候打过天花疫苗吗?
9 investigation MRKzq     
n.调查,调查研究
参考例句:
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。
10 analogous aLdyQ     
adj.相似的;类似的
参考例句:
  • The two situations are roughly analogous.两种情況大致相似。
  • The company is in a position closely analogous to that of its main rival.该公司与主要竞争对手的处境极为相似。
11 inquiry nbgzF     
n.打听,询问,调查,查问
参考例句:
  • Many parents have been pressing for an inquiry into the problem.许多家长迫切要求调查这个问题。
  • The field of inquiry has narrowed down to five persons.调查的范围已经缩小到只剩5个人了。
12 essentially nntxw     
adv.本质上,实质上,基本上
参考例句:
  • Really great men are essentially modest.真正的伟人大都很谦虚。
  • She is an essentially selfish person.她本质上是个自私自利的人。
13 affected TzUzg0     
adj.不自然的,假装的
参考例句:
  • She showed an affected interest in our subject.她假装对我们的课题感到兴趣。
  • His manners are affected.他的态度不自然。
14 eruption UomxV     
n.火山爆发;(战争等)爆发;(疾病等)发作
参考例句:
  • The temple was destroyed in the violent eruption of 1470 BC.庙宇在公元前1470年猛烈的火山爆发中摧毁了。
  • The eruption of a volcano is spontaneous.火山的爆发是自发的。
15 eruptions ca60b8eba3620efa5cdd7044f6dd0b66     
n.喷发,爆发( eruption的名词复数 )
参考例句:
  • There have been several volcanic eruptions this year. 今年火山爆发了好几次。 来自《简明英汉词典》
  • Over 200 people have been killed by volcanic eruptions. 火山喷发已导致200多人丧生。 来自辞典例句
16 perfectly 8Mzxb     
adv.完美地,无可非议地,彻底地
参考例句:
  • The witnesses were each perfectly certain of what they said.证人们个个对自己所说的话十分肯定。
  • Everything that we're doing is all perfectly above board.我们做的每件事情都是光明正大的。
17 distinguished wu9z3v     
adj.卓越的,杰出的,著名的
参考例句:
  • Elephants are distinguished from other animals by their long noses.大象以其长长的鼻子显示出与其他动物的不同。
  • A banquet was given in honor of the distinguished guests.宴会是为了向贵宾们致敬而举行的。
18 applied Tz2zXA     
adj.应用的;v.应用,适用
参考例句:
  • She plans to take a course in applied linguistics.她打算学习应用语言学课程。
  • This cream is best applied to the face at night.这种乳霜最好晚上擦脸用。
19 previously bkzzzC     
adv.以前,先前(地)
参考例句:
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
20 rev njvzwS     
v.发动机旋转,加快速度
参考例句:
  • It's his job to rev up the audience before the show starts.他要负责在表演开始前鼓动观众的热情。
  • Don't rev the engine so hard.别让发动机转得太快。
21 scattered 7jgzKF     
adj.分散的,稀疏的;散步的;疏疏落落的
参考例句:
  • Gathering up his scattered papers,he pushed them into his case.他把散乱的文件收拾起来,塞进文件夹里。
22 pimples f06a6536c7fcdeca679ac422007b5c89     
n.丘疹,粉刺,小脓疱( pimple的名词复数 )
参考例句:
  • It gave me goose pimples just to think about it. 只是想到它我就起鸡皮疙瘩。
  • His face has now broken out in pimples. 他脸上突然起了丘疹。 来自《简明英汉词典》
23 apex mwrzX     
n.顶点,最高点
参考例句:
  • He reached the apex of power in the early 1930s.他在三十年代初达到了权力的顶峰。
  • His election to the presidency was the apex of his career.当选总统是他一生事业的顶峰。
24 cuticular 568986bcf485a9b50440a5ec178dce46     
adj.表皮的
参考例句:
  • Commonly bacterium of gules and cuticular tinea waits. 常见的有红色表皮癣菌等。 来自互联网
  • Cuticular cell organization and embedded material call the skin to protect wet organization jointly. 表皮细胞组织与内含物质共同称为皮肤保湿机构。 来自互联网
25 acrid TJEy4     
adj.辛辣的,尖刻的,刻薄的
参考例句:
  • There is an acrid tone to your remarks.你说这些话的口气带有讥刺意味。
  • The room was filled with acrid smoke.房里充满刺鼻的烟。
26 irritable LRuzn     
adj.急躁的;过敏的;易怒的
参考例句:
  • He gets irritable when he's got toothache.他牙一疼就很容易发脾气。
  • Our teacher is an irritable old lady.She gets angry easily.我们的老师是位脾气急躁的老太太。她很容易生气。
27 allude vfdyW     
v.提及,暗指
参考例句:
  • Many passages in Scripture allude to this concept.圣经中有许多经文间接地提到这样的概念。
  • She also alluded to her rival's past marital troubles.她还影射了对手过去的婚姻问题。
28 considerably 0YWyQ     
adv.极大地;相当大地;在很大程度上
参考例句:
  • The economic situation has changed considerably.经济形势已发生了相当大的变化。
  • The gap has narrowed considerably.分歧大大缩小了。
29 premises 6l1zWN     
n.建筑物,房屋
参考例句:
  • According to the rules,no alcohol can be consumed on the premises.按照规定,场内不准饮酒。
  • All repairs are done on the premises and not put out.全部修缮都在家里进行,不用送到外面去做。
30 extinction sPwzP     
n.熄灭,消亡,消灭,灭绝,绝种
参考例句:
  • The plant is now in danger of extinction.这种植物现在有绝种的危险。
  • The island's way of life is doomed to extinction.这个岛上的生活方式注定要消失。
31 peculiar cinyo     
adj.古怪的,异常的;特殊的,特有的
参考例句:
  • He walks in a peculiar fashion.他走路的样子很奇特。
  • He looked at me with a very peculiar expression.他用一种很奇怪的表情看着我。
32 inexplicable tbCzf     
adj.无法解释的,难理解的
参考例句:
  • It is now inexplicable how that development was misinterpreted.当时对这一事态发展的错误理解究竟是怎么产生的,现在已经无法说清楚了。
  • There are many things which are inexplicable by science.有很多事科学还无法解释。
33 modification tEZxm     
n.修改,改进,缓和,减轻
参考例句:
  • The law,in its present form,is unjust;it needs modification.现行的法律是不公正的,它需要修改。
  • The design requires considerable modification.这个设计需要作大的修改。
34 elucidate GjSzd     
v.阐明,说明
参考例句:
  • The note help to elucidate the most difficult parts of the text.这些注释有助于弄清文中最难懂的部分。
  • This guide will elucidate these differences and how to exploit them.这篇指导将会阐述这些不同点以及如何正确利用它们。
35 pampered pampered     
adj.饮食过量的,饮食奢侈的v.纵容,宠,娇养( pamper的过去式和过去分词 )
参考例句:
  • The lazy scum deserve worse. What if they ain't fed up and pampered? 他们吃不饱,他们的要求满足不了,这又有什么关系? 来自飘(部分)
  • She petted and pampered him and would let no one discipline him but she, herself. 她爱他,娇养他,而且除了她自己以外,她不允许任何人管教他。 来自辞典例句
36 metropolis BCOxY     
n.首府;大城市
参考例句:
  • Shanghai is a metropolis in China.上海是中国的大都市。
  • He was dazzled by the gaiety and splendour of the metropolis.大都市的花花世界使他感到眼花缭乱。
37 procure A1GzN     
vt.获得,取得,促成;vi.拉皮条
参考例句:
  • Can you procure some specimens for me?你能替我弄到一些标本吗?
  • I'll try my best to procure you that original French novel.我将尽全力给你搞到那本原版法国小说。
38 procured 493ee52a2e975a52c94933bb12ecc52b     
v.(努力)取得, (设法)获得( procure的过去式和过去分词 );拉皮条
参考例句:
  • These cars are to be procured through open tender. 这些汽车要用公开招标的办法购买。 来自《现代汉英综合大词典》
  • A friend procured a position in the bank for my big brother. 一位朋友为我哥哥谋得了一个银行的职位。 来自《用法词典》
39 determined duszmP     
adj.坚定的;有决心的
参考例句:
  • I have determined on going to Tibet after graduation.我已决定毕业后去西藏。
  • He determined to view the rooms behind the office.他决定查看一下办公室后面的房间。
40 nugatory 5HWxG     
adj.琐碎的,无价值的
参考例句:
  • Your efforts shall have been nugatory.你的努力也就没有价值了。
  • These are all nugatory comment.这些都是空洞的评论。
41 retired Njhzyv     
adj.隐退的,退休的,退役的
参考例句:
  • The old man retired to the country for rest.这位老人下乡休息去了。
  • Many retired people take up gardening as a hobby.许多退休的人都以从事园艺为嗜好。
42 sufficiently 0htzMB     
adv.足够地,充分地
参考例句:
  • It turned out he had not insured the house sufficiently.原来他没有给房屋投足保险。
  • The new policy was sufficiently elastic to accommodate both views.新政策充分灵活地适用两种观点。
43 vigour lhtwr     
(=vigor)n.智力,体力,精力
参考例句:
  • She is full of vigour and enthusiasm.她有热情,有朝气。
  • At 40,he was in his prime and full of vigour.他40岁时正年富力强。
44 infinitely 0qhz2I     
adv.无限地,无穷地
参考例句:
  • There is an infinitely bright future ahead of us.我们有无限光明的前途。
  • The universe is infinitely large.宇宙是无限大的。
45 alluded 69f7a8b0f2e374aaf5d0965af46948e7     
提及,暗指( allude的过去式和过去分词 )
参考例句:
  • In your remarks you alluded to a certain sinister design. 在你的谈话中,你提到了某个阴谋。
  • She also alluded to her rival's past marital troubles. 她还影射了对手过去的婚姻问题。
46 alteration rxPzO     
n.变更,改变;蚀变
参考例句:
  • The shirt needs alteration.这件衬衣需要改一改。
  • He easily perceived there was an alteration in my countenance.他立刻看出我的脸色和往常有些不同。
47 recurring 8kLzK8     
adj.往复的,再次发生的
参考例句:
  • This kind of problem is recurring often. 这类问题经常发生。
  • For our own country, it has been a time for recurring trial. 就我们国家而言,它经过了一个反复考验的时期。
48 subscribe 6Hozu     
vi.(to)订阅,订购;同意;vt.捐助,赞助
参考例句:
  • I heartily subscribe to that sentiment.我十分赞同那个观点。
  • The magazine is trying to get more readers to subscribe.该杂志正大力发展新订户。
49 prosecute d0Mzn     
vt.告发;进行;vi.告发,起诉,作检察官
参考例句:
  • I am trying my best to prosecute my duties.我正在尽力履行我的职责。
  • Is there enough evidence to prosecute?有没有起诉的足够证据?
50 inquiries 86a54c7f2b27c02acf9fcb16a31c4b57     
n.调查( inquiry的名词复数 );疑问;探究;打听
参考例句:
  • He was released on bail pending further inquiries. 他获得保释,等候进一步调查。
  • I have failed to reach them by postal inquiries. 我未能通过邮政查询与他们取得联系。 来自《现代汉英综合大词典》
51 enumerated 837292cced46f73066764a6de97d6d20     
v.列举,枚举,数( enumerate的过去式和过去分词 )
参考例句:
  • A spokesperson enumerated the strikers' demands. 发言人列数罢工者的要求。 来自《简明英汉词典》
  • He enumerated the capitals of the 50 states. 他列举了50个州的首府。 来自《现代汉英综合大词典》
52 deviation Ll0zv     
n.背离,偏离;偏差,偏向;离题
参考例句:
  • Deviation from this rule are very rare.很少有违反这条规则的。
  • Any deviation from the party's faith is seen as betrayal.任何对党的信仰的偏离被视作背叛。
53 formerly ni3x9     
adv.从前,以前
参考例句:
  • We now enjoy these comforts of which formerly we had only heard.我们现在享受到了过去只是听说过的那些舒适条件。
  • This boat was formerly used on the rivers of China.这船从前航行在中国内河里。
54 vitriolic wHnyP     
adj.硫酸的,尖刻的
参考例句:
  • The newspaper launched a vitriolic attack on the president.这家报纸对总统发起了一场恶意的攻击。
  • Vitriolic impurity is contained normally in the sewage that vitriolic factory discharges.硫酸厂排放的污水中通常含有硫酸杂质。
55 utensil 4KjzJ     
n.器皿,用具
参考例句:
  • The best carving utensil is a long, sharp, flexible knife.最好的雕刻工具是锋利而柔韧的长刻刀。
  • Wok is a very common cooking utensil in every Chinese family.炒菜锅是每个中国人家庭里很常用的厨房食用具。
56 requisite 2W0xu     
adj.需要的,必不可少的;n.必需品
参考例句:
  • He hasn't got the requisite qualifications for the job.他不具备这工作所需的资格。
  • Food and air are requisite for life.食物和空气是生命的必需品。
57 fully Gfuzd     
adv.完全地,全部地,彻底地;充分地
参考例句:
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
58 supersede zrXwz     
v.替代;充任
参考例句:
  • We must supersede old machines by new ones.我们必须以新机器取代旧机器。
  • The use of robots will someday supersede manual labor.机器人的使用有一天会取代人力。
59 physiology uAfyL     
n.生理学,生理机能
参考例句:
  • He bought a book about physiology.他买了一本生理学方面的书。
  • He was awarded the Nobel Prize for achievements in physiology.他因生理学方面的建树而被授予诺贝尔奖。
60 deviating c570dfa313c71c6bf38456f4f07d66d7     
v.偏离,越轨( deviate的现在分词 )
参考例句:
  • I compromise by using a prepared text and deviating from it whenever I feel the need. 我搞折衷办法,准备一份讲稿,觉得需要的时候就自由发挥。 来自辞典例句
  • Theories deviating practices are inane, while practices deviating theories are blindfold. 脱离实践的理论是空泛的,脱离理论指导的实践是盲目的。 来自互联网
61 perusal mM5xT     
n.细读,熟读;目测
参考例句:
  • Peter Cooke undertook to send each of us a sample contract for perusal.彼得·库克答应给我们每人寄送一份合同样本供阅读。
  • A perusal of the letters which we have published has satisfied him of the reality of our claim.读了我们的公开信后,他终于相信我们的要求的确是真的。
62 derived 6cddb7353e699051a384686b6b3ff1e2     
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取
参考例句:
  • Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
  • He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》
63 dispersed b24c637ca8e58669bce3496236c839fa     
adj. 被驱散的, 被分散的, 散布的
参考例句:
  • The clouds dispersed themselves. 云散了。
  • After school the children dispersed to their homes. 放学后,孩子们四散回家了。
64 regiment JATzZ     
n.团,多数,管理;v.组织,编成团,统制
参考例句:
  • As he hated army life,he decide to desert his regiment.因为他嫌恶军队生活,所以他决心背弃自己所在的那个团。
  • They reformed a division into a regiment.他们将一个师整编成为一个团。
65 militia 375zN     
n.民兵,民兵组织
参考例句:
  • First came the PLA men,then the people's militia.人民解放军走在前面,其次是民兵。
  • There's a building guarded by the local militia at the corner of the street.街道拐角处有一幢由当地民兵团守卫的大楼。
66 puncture uSUxj     
n.刺孔,穿孔;v.刺穿,刺破
参考例句:
  • Failure did not puncture my confidence.失败并没有挫伤我的信心。
  • My bicycle had a puncture and needed patching up.我的自行车胎扎了个洞,需要修补。
67 accurately oJHyf     
adv.准确地,精确地
参考例句:
  • It is hard to hit the ball accurately.准确地击中球很难。
  • Now scientists can forecast the weather accurately.现在科学家们能准确地预报天气。
68 mercurial yCnxD     
adj.善变的,活泼的
参考例句:
  • He was of a mercurial temperament and therefore unpredictable.他是个反复无常的人,因此对他的行为无法预言。
  • Our desires and aversions are mercurial rulers.我们的欲望与嫌恶是变化无常的统治者。
69 ointment 6vzy5     
n.药膏,油膏,软膏
参考例句:
  • Your foot will feel better after the application of this ointment.敷用这药膏后,你的脚会感到舒服些。
  • This herbal ointment will help to close up your wound quickly.这种中草药膏会帮助你的伤口很快愈合。
70 inflamed KqEz2a     
adj.发炎的,红肿的v.(使)变红,发怒,过热( inflame的过去式和过去分词 )
参考例句:
  • His comments have inflamed teachers all over the country. 他的评论激怒了全国教师。
  • Her joints are severely inflamed. 她的关节严重发炎。 来自《简明英汉词典》
71 languor V3wyb     
n.无精力,倦怠
参考例句:
  • It was hot,yet with a sweet languor about it.天气是炎热的,然而却有一种惬意的懒洋洋的感觉。
  • She,in her languor,had not troubled to eat much.她懒懒的,没吃多少东西。
72 incipient HxFyw     
adj.起初的,发端的,初期的
参考例句:
  • The anxiety has been sharpened by the incipient mining boom.采矿业初期的蓬勃发展加剧了这种担忧。
  • What we see then is an incipient global inflation.因此,我们看到的是初期阶段的全球通胀.
73 subsided 1bda21cef31764468020a8c83598cc0d     
v.(土地)下陷(因在地下采矿)( subside的过去式和过去分词 );减弱;下降至较低或正常水平;一下子坐在椅子等上
参考例句:
  • After the heavy rains part of the road subsided. 大雨过后,部分公路塌陷了。 来自《简明英汉词典》
  • By evening the storm had subsided and all was quiet again. 傍晚, 暴风雨已经过去,四周开始沉寂下来。 来自《现代汉英综合大词典》
74 cuticle innzc     
n.表皮
参考例句:
  • You'd never puncture the cuticle.你无法刺穿表皮。
  • The reform has hardly made a scratch upon the cuticle of affairs.改革几乎还没有触到事物的表皮。
75 partially yL7xm     
adv.部分地,从某些方面讲
参考例句:
  • The door was partially concealed by the drapes.门有一部分被门帘遮住了。
  • The police managed to restore calm and the curfew was partially lifted.警方设法恢复了平静,宵禁部分解除。
76 entirely entirely     
ad.全部地,完整地;完全地,彻底地
参考例句:
  • The fire was entirely caused by their neglect of duty. 那场火灾完全是由于他们失职而引起的。
  • His life was entirely given up to the educational work. 他的一生统统献给了教育工作。
77 plentiful r2izH     
adj.富裕的,丰富的
参考例句:
  • Their family has a plentiful harvest this year.他们家今年又丰收了。
  • Rainfall is plentiful in the area.这个地区雨量充足。
78 vomiting 7ed7266d85c55ba00ffa41473cf6744f     
参考例句:
  • Symptoms include diarrhoea and vomiting. 症状有腹泻和呕吐。
  • Especially when I feel seasick, I can't stand watching someone else vomiting." 尤其晕船的时候,看不得人家呕。”
79 punctured 921f9ed30229127d0004d394b2c18311     
v.在(某物)上穿孔( puncture的过去式和过去分词 );刺穿(某物);削弱(某人的傲气、信心等);泄某人的气
参考例句:
  • Some glass on the road punctured my new tyre. 路上的玻璃刺破了我的新轮胎。 来自《简明英汉词典》
  • A nail on the road punctured the tyre. 路上的钉子把车胎戳穿了。 来自《现代汉英综合大词典》
80 casually UwBzvw     
adv.漠不关心地,无动于衷地,不负责任地
参考例句:
  • She remarked casually that she was changing her job.她当时漫不经心地说要换工作。
  • I casually mentioned that I might be interested in working abroad.我不经意地提到我可能会对出国工作感兴趣。
81 propriety oRjx4     
n.正当行为;正当;适当
参考例句:
  • We hesitated at the propriety of the method.我们对这种办法是否适用拿不定主意。
  • The sensitive matter was handled with great propriety.这件机密的事处理得极为适当。
82 inoculating 9e3023b2654258e7ea140f88a7ddd22b     
v.给…做预防注射( inoculate的现在分词 )
参考例句:
  • He attempted to investigate bidirectional streaming by inoculating two dishes with R. oryzae. 他试图研究双向流动的问题,他把未根霉接种于两个培养皿。 来自辞典例句
  • Doctors examined the recruits but nurses did the inocuLating. 医生们给新兵检查了身体,护士们给他们打了预防针。 来自互联网
83 contagion 9ZNyl     
n.(通过接触的疾病)传染;蔓延
参考例句:
  • A contagion of fear swept through the crowd.一种恐惧感在人群中迅速蔓延开。
  • The product contagion effect has numerous implications for marketing managers and retailers.产品传染效应对市场营销管理者和零售商都有很多的启示。
84 malady awjyo     
n.病,疾病(通常做比喻)
参考例句:
  • There is no specific remedy for the malady.没有医治这种病的特效药。
  • They are managing to control the malady into a small range.他们设法将疾病控制在小范围之内。
85 maturity 47nzh     
n.成熟;完成;(支票、债券等)到期
参考例句:
  • These plants ought to reach maturity after five years.这些植物五年后就该长成了。
  • This is the period at which the body attains maturity.这是身体发育成熟的时期。
86 remarkable 8Vbx6     
adj.显著的,异常的,非凡的,值得注意的
参考例句:
  • She has made remarkable headway in her writing skills.她在写作技巧方面有了长足进步。
  • These cars are remarkable for the quietness of their engines.这些汽车因发动机没有噪音而不同凡响。
87 intervention e5sxZ     
n.介入,干涉,干预
参考例句:
  • The government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
  • Many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。
88 ascertaining e416513cdf74aa5e4277c1fc28aab393     
v.弄清,确定,查明( ascertain的现在分词 )
参考例句:
  • I was ascertaining whether the cellar stretched out in front or behind. 我当时是要弄清楚地下室是朝前还是朝后延伸的。 来自辞典例句
  • The design and ascertaining of permanent-magnet-biased magnetic bearing parameter are detailed introduced. 并对永磁偏置磁悬浮轴承参数的设计和确定进行了详细介绍。 来自互联网
89 exhaling 7af647e9d65b476b7a2a4996fd007529     
v.呼出,发散出( exhale的现在分词 );吐出(肺中的空气、烟等),呼气
参考例句:
  • Take a deep breath inhaling slowly and exhaling slowly. 深呼吸,慢慢吸进,慢慢呼出。 来自互联网
  • Unclasp your hands and return to the original position while exhaling. 呼气并松开双手恢复到原位。 来自互联网
90 scrutiny ZDgz6     
n.详细检查,仔细观察
参考例句:
  • His work looks all right,but it will not bear scrutiny.他的工作似乎很好,但是经不起仔细检查。
  • Few wives in their forties can weather such a scrutiny.很少年过四十的妻子经得起这么仔细的观察。
91 inhaled 1072d9232d676d367b2f48410158ae32     
v.吸入( inhale的过去式和过去分词 )
参考例句:
  • She closed her eyes and inhaled deeply. 她合上双眼,深深吸了一口气。
  • Janet inhaled sharply when she saw him. 珍妮特看到他时猛地吸了口气。 来自《简明英汉词典》
92 nostrils 23a65b62ec4d8a35d85125cdb1b4410e     
鼻孔( nostril的名词复数 )
参考例句:
  • Her nostrils flared with anger. 她气得两个鼻孔都鼓了起来。
  • The horse dilated its nostrils. 马张大鼻孔。
93 manifestation 0RCz6     
n.表现形式;表明;现象
参考例句:
  • Her smile is a manifestation of joy.她的微笑是她快乐的表现。
  • What we call mass is only another manifestation of energy.我们称之为质量的东西只是能量的另一种表现形态。
94 limpid 43FyK     
adj.清澈的,透明的
参考例句:
  • He has a pair of limpid blue eyes.他有一双清澈的蓝眼睛。
  • The sky was a limpid blue,as if swept clean of everything.碧空如洗。
95 rugged yXVxX     
adj.高低不平的,粗糙的,粗壮的,强健的
参考例句:
  • Football players must be rugged.足球运动员必须健壮。
  • The Rocky Mountains have rugged mountains and roads.落基山脉有崇山峻岭和崎岖不平的道路。
96 texture kpmwQ     
n.(织物)质地;(材料)构造;结构;肌理
参考例句:
  • We could feel the smooth texture of silk.我们能感觉出丝绸的光滑质地。
  • Her skin has a fine texture.她的皮肤细腻。
97 laborious VxoyD     
adj.吃力的,努力的,不流畅
参考例句:
  • They had the laborious task of cutting down the huge tree.他们接受了伐大树的艰苦工作。
  • Ants and bees are laborious insects.蚂蚁与蜜蜂是勤劳的昆虫。
98 anomalous MwbzI     
adj.反常的;不规则的
参考例句:
  • For years this anomalous behaviour has baffled scientists.几年来这种反常行为让科学家们很困惑。
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
99 friction JQMzr     
n.摩擦,摩擦力
参考例句:
  • When Joan returned to work,the friction between them increased.琼回来工作后,他们之间的摩擦加剧了。
  • Friction acts on moving bodies and brings them to a stop.摩擦力作用于运动着的物体,并使其停止。
100 subdued 76419335ce506a486af8913f13b8981d     
adj. 屈服的,柔和的,减弱的 动词subdue的过去式和过去分词
参考例句:
  • He seemed a bit subdued to me. 我觉得他当时有点闷闷不乐。
  • I felt strangely subdued when it was all over. 一切都结束的时候,我却有一种奇怪的压抑感。
101 linen W3LyK     
n.亚麻布,亚麻线,亚麻制品;adj.亚麻布制的,亚麻的
参考例句:
  • The worker is starching the linen.这名工人正在给亚麻布上浆。
  • Fine linen and cotton fabrics were known as well as wool.精细的亚麻织品和棉织品像羊毛一样闻名遐迩。
102 prematurely nlMzW4     
adv.过早地,贸然地
参考例句:
  • She was born prematurely with poorly developed lungs. 她早产,肺部未发育健全。 来自《简明英汉词典》
  • His hair was prematurely white, but his busy eyebrows were still jet-black. 他的头发已经白了,不过两道浓眉还是乌黑乌黑的。 来自辞典例句
103 treatises 9ff9125c93810e8709abcafe0c3289ca     
n.专题著作,专题论文,专著( treatise的名词复数 )
参考例句:
  • Many treatises in different languages have been published on pigeons. 关于鸽类的著作,用各种文字写的很多。 来自辞典例句
  • Many other treatises incorporated the new rigor. 许多其它的专题论文体现了新的严密性。 来自辞典例句
104 corroboration vzoxo     
n.进一步的证实,进一步的证据
参考例句:
  • Without corroboration from forensic tests,it will be difficult to prove that the suspect is guilty. 没有法医化验的确证就很难证明嫌疑犯有罪。 来自《简明英汉词典》
  • Definitely more independent corroboration is necessary. 有必要更明确地进一步证实。 来自辞典例句
105 corroborate RoVzf     
v.支持,证实,确定
参考例句:
  • He looked at me anxiously,as if he hoped I'd corroborate this.他神色不安地看着我,仿佛他希望我证实地的话。
  • It appeared that what he said went to corroborate my account.看来他所说的和我叙述的相符。
106 infancy F4Ey0     
n.婴儿期;幼年期;初期
参考例句:
  • He came to England in his infancy.他幼年时期来到英国。
  • Their research is only in its infancy.他们的研究处于初级阶段。
107 positively vPTxw     
adv.明确地,断然,坚决地;实在,确实
参考例句:
  • She was positively glowing with happiness.她满脸幸福。
  • The weather was positively poisonous.这天气着实讨厌。
108 practitioner 11Rzh     
n.实践者,从事者;(医生或律师等)开业者
参考例句:
  • He is an unqualified practitioner of law.他是个无资格的律师。
  • She was a medical practitioner before she entered politics.从政前她是个开业医生。
109 foe ygczK     
n.敌人,仇敌
参考例句:
  • He knew that Karl could be an implacable foe.他明白卡尔可能会成为他的死敌。
  • A friend is a friend;a foe is a foe;one must be clearly distinguished from the other.敌是敌,友是友,必须分清界限。
110 attentively AyQzjz     
adv.聚精会神地;周到地;谛;凝神
参考例句:
  • She listened attentively while I poured out my problems. 我倾吐心中的烦恼时,她一直在注意听。 来自《简明英汉词典》
  • She listened attentively and set down every word he said. 她专心听着,把他说的话一字不漏地记下来。 来自《简明英汉词典》
111 promulgated a4e9ce715ee72e022795b8072a6e618f     
v.宣扬(某事物)( promulgate的过去式和过去分词 );传播;公布;颁布(法令、新法律等)
参考例句:
  • Hence China has promulgated more than 30 relevant laws, statutes and regulations. 中国为此颁布的法律、法规和规章多达30余项。 来自汉英非文学 - 白皮书
  • The shipping industry promulgated a voluntary code. 航运业对自律守则进行了宣传。 来自辞典例句
112 doctrine Pkszt     
n.教义;主义;学说
参考例句:
  • He was impelled to proclaim his doctrine.他不得不宣扬他的教义。
  • The council met to consider changes to doctrine.宗教议会开会考虑更改教义。
113 rigid jDPyf     
adj.严格的,死板的;刚硬的,僵硬的
参考例句:
  • She became as rigid as adamant.她变得如顽石般的固执。
  • The examination was so rigid that nearly all aspirants were ruled out.考试很严,几乎所有的考生都被淘汰了。
114 temerity PGmyk     
n.鲁莽,冒失
参考例句:
  • He had the temerity to ask for higher wages after only a day's work.只工作了一天,他就蛮不讲理地要求增加工资。
  • Tins took some temerity,but it was fruitless.这件事做得有点莽撞,但结果还是无用。
115 assailable 7782dcc946b9b546fe73a100a09102b0     
adj.可攻击的,易攻击的
参考例句:
116 beholding 05d0ea730b39c90ee12d6e6b8c193935     
v.看,注视( behold的现在分词 );瞧;看呀;(叙述中用于引出某人意外的出现)哎哟
参考例句:
  • Beholding, besides love, the end of love,/Hearing oblivion beyond memory! 我看见了爱,还看到了爱的结局,/听到了记忆外层的哪一片寂寥! 来自英汉 - 翻译样例 - 文学
  • Hence people who began by beholding him ended by perusing him. 所以人们从随便看一看他开始的,都要以仔细捉摸他而终结。 来自辞典例句
117 antidote 4MZyg     
n.解毒药,解毒剂
参考例句:
  • There is no known antidote for this poison.这种毒药没有解药。
  • Chinese physicians used it as an antidote for snake poison.中医师用它来解蛇毒。
118 extirpating f0c51c6a65e56da16f46a1738f641978     
v.消灭,灭绝( extirpate的现在分词 );根除
参考例句:
119 devouring c4424626bb8fc36704aee0e04e904dcf     
吞没( devour的现在分词 ); 耗尽; 津津有味地看; 狼吞虎咽地吃光
参考例句:
  • The hungry boy was devouring his dinner. 那饥饿的孩子狼吞虎咽地吃饭。
  • He is devouring novel after novel. 他一味贪看小说。
120 scourge FD2zj     
n.灾难,祸害;v.蹂躏
参考例句:
  • Smallpox was once the scourge of the world.天花曾是世界的大患。
  • The new boss was the scourge of the inefficient.新老板来了以后,不称职的人就遭殃了。


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